Regional Hemodynamic Effects of Candesartan Cilexetil (TCV : 116),an Angiotensin II AT_1 : Receptor Antagonist,in Conscious Spontaneously Hypertensive Rats
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概要
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The regional hemodynamic effects of candesartan cilexetil (TCV-116), a selective angiotensin II AT<SUB>1</SUB>-receptor antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, were compared in conscious spontaneously hypertensive rats (SHR). A 7-day repeated administration study was carried out. TCV-116 (1 mg/kg, p.o.)and enalapril (10 mg/kg, p.o.)reduced blood pressure to the same extent 5 hr after administration on the 1st and the 7th day. At these points, the cardiac index and organ or tissue blood flow were measured by the non-radioactive colored dye-extraction microsphere technique. Repeated administration of TCV-116, and single and repeated administration of enalapril significantly increased renal blood flow without any changes in the cardiac index. TCV-116 and enalapril also tended to increase splanchnic blood flow following the 1st dose but not the 7th dose. No significant changes in blood flow were observed in the brain, heart, adrenal, skin and skeletal muscle. These results suggest that the antihypertensive effects of TCV-116 and enalapril are attributable to the systemic reduction of vascular resistance caused by the dilatation of blood vessels. These hemodynamic effects of TCV-116, like those of enalapril, may be beneficial in the treatment of hypertension.
- 社団法人 日本薬理学会の論文
- 1997-03-01
著者
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Wada Takeo
Pharmaceutical Research Laboratories Ii Phoarmaceutical Research Division Takeda Chemical Industries
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Wada Takeo
Pharmaceutical Research Division Takeda Chemical Industry Co. Ltd.
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Wada T
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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Inada Yoshiyuki
Pharmaceutical Research Laboratories Ii Phoarmaceutical Research Division Takeda Chemical Industries
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Inada Yoshiyuki
Pharmaceutical Research Division Takeda Chemical Industry Co. Ltd.
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Sanada Tsukasa
Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd.
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Kanagawa Ray
Pharmaceutical Research Laboratories Ii Phoarmaceutical Research Division Takeda Chemical Industries
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OJIMA Nami
Pharmaceutical Research Laboratories II,Phoarmaceutical Research Division,Takeda Chemical Industries
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Sanada Tsukasa
Pharmaceutical Research Laboratories Ii Phoarmaceutical Research Division Takeda Chemical Industries
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Ojima Nami
Pharmaceutical Research Laboratories Ii Phoarmaceutical Research Division Takeda Chemical Industries
関連論文
- Inhibition of the Angiotensin II Type 1 Receptor by TCV-116: Quantitation by In Vitro Autoradiography
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- Regional Hemodynamic Effects of Candesartan Cilexetil (TCV : 116),an Angiotensin II AT_1 : Receptor Antagonist,in Conscious Spontaneously Hypertensive Rats
- Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil (TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats
- Discovery of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: The Synthesis, Biological Evaluation, and Reduced Adrenal Toxicity of (4-Phenylcoumarin)acetanilide Derivatives with a Carboxylic Acid Moiety