A recursive procedure to compute the gametic relationship matrix and its inverse for marked QTL clusters

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概要

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• Recently, a variety of mixed linear models have been proposed for marker-assisted prediction of the effects of quantitative trait loci (QTLs) in outbred populations of animals. One of them addresses the effects of a cluster of linked QTLs, or those of a particular chromosomal segment, marked by DNA marker(s) and requires that the inverse of the corresponding gametic relationship matrix whose elements are the conditional expected values of the identity-by-descent (IBD) proportions between gametes for individuals be evaluated. Here, for a model of this type, utilizing the property of the IBD set and using the information on the joint gametogenesis processes at the flanking marker loci, we present a recursive method to systematically calculate the elements of the gametic relationship matrix and its inverse. A numerical example is given to illustrate the proposed computing procedure.

• 日本遺伝学会の論文
• 2002-04-01

著者

• Matsuda Hirokazu

  Course Of Environmental Management Science Graduate School Of Science And Technology

• Iwaisaki Hiroaki

  Course Of Environmental Management Science Graduate School Of Science And Technology

関連論文

• A comparison of interval mapping procedures including the QTL-cluster mapping
• Best Linear Unbiased Prediction of QTLs-Cluster Effects Using Flanking and Upstream Marker Information in Outbred Populations
• Relative accuracy expected in marker-assisted combined selection for quantitative characters in outbred populations
• Best linear unbiased prediction of additive genetic merit using a combined-merit sire and dam model for marker-assisted selection
• Calculating Elements of Gametic Relationship Matrix in the Model Containing Effects of Marked QTL-Cluster
• A recursive procedure to compute the gametic relationship matrix and its inverse for marked QTL clusters

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