Variability in Cholesteryl Ester Transfer Protein in Healthy Japanese Hyper-HDL-cholesterolemic Subjects
スポンサーリンク
概要
- 論文の詳細を見る
Objective Hyper-high density lipoprotein (HDL)-cholesterolemia has been considered to be anti-atherogenic and is referred to as longevity syndrome. However, hyper-HDL-cholesterolemia induced by a cholesteryl ester transfer protein (CETP) deficiency may not be athero-protective, rather being atherogenic in nature. In a rural area in central Japan, the incidence of hyper-HDL-cholesterolemia has been found to be rather high (3.1% of healthy people). We studied healthy Japanese people in this area with hyper-HDL-cholesterolemia, particularly in relation to CETP.Methods Serum lipids were analyzed, and CETP mass was determined with an enzyme immunoassay method.Materials Blood was drawn after an overnight fast from 17 Japanese (5 males and 12 females) with serum HDL-cholesterol (C) ≥100 mg/dl.Results Serum CETP mass in hyper-HDL-cholesterolemic subjects was distributed in a wide range. Serum CETP mass was positively correlated with low-density lipoprotein (LDL)-C, apolipoprotein (Apo) B, and LDL-C/HDL-C, with statistical significance. CETP was also positively correlated with LDL-C/Apo B.Conclusion These results suggest that hyper-HDL-cholesterolemia may not be a single clinical entity, but a mixture of various pathophysiological conditions, and that the ratio of LDL-C to HDL-C and the size of LDL may be important factors in classifying these conditions.(Internal Medicine 41: 357-359, 2002)
- 社団法人 日本内科学会の論文
- 2002-05-01
著者
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Naito Michitaka
The Department Of Geriatrics Nagoya University School Of Medicine
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Naito Michitaka
The Division Of Nutrition And Health Graduate School Of Life Studies Sugiyama Jogakuen University
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Kobayashi Norifumi
Osaka Research Laboratories Wako Pure Chemical Industries
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Nomura Hideki
The Department Of Geriatrics Nagoya University Graduate School Of Medicine
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YOSHIDA Akihiko
The Department of Clinical Laboratory, Nakatsugawa Municipal Hospital
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KOMADA Michiteru
The Department of Geriatrics, Nagoya University Graduate School of Medicine
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SUMIDA Kyoichi
Osaka Research Laboratories, Wako Pure Chemical Industries
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Komada Michiteru
The Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Sumida Kyoichi
Osaka Research Laboratories Wako Pure Chemical Industries
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Yoshida Akihiko
The Department Of Clinical Laboratory Nakatsugawa Municipal Hospital
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Yoshida Akihiro
The Department of Clinical Laboratory, Nakatsugawa Municipal Hospital
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