Identification of Kallidin Degrading Enzymes in the Isolated Perfused Rat Heart
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概要
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Kallidin (KD) is an important vasoactive kinin whose physiological effects are strongly dependent on its degradation through local kininases. In the present study, we examined the spectrum of these enzymes and their contribution to KD degradation in isolated perfused rat hearts. By inhibiting angiotensin-converting enzyme (ACE), aminopeptidase M (APM) and neutral endopeptidase (NEP) with ramiprilat (0.25 μM), amastatin (40 μM) and phosphoramidon (1 μM), respectively, relative kininase activities were obtained. APM (44%) and ACE (35%) are the main KD degrading enzymes in rat heart; NEP (7%) plays a minor role. A participation of carboxypeptidase N (CPN) could not be found.
- 社団法人 日本薬理学会の論文
著者
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Dendorfer Andreas
Institute Of Experimental And Clinical Pharmacology And Toxicology Medical University Of Lubeck
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Dominiak P
Institute Of Experimental And Clinical Pharmacology And Toxicology Medical University Of Lubeck
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Dominiak Peter
Institute For Experimental And Clinical Pharmacology And Toxicology Medical University Of Lubeck
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WOLFRUM Sebastian
Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Ltibeck
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Wolfrum Sebastian
Institute Of Pharmacology Medical University Of Lubeck
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