Effect of 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole HCl (MKC-242), a Novel 5-HT_<1A>-Receptor Agonist, on Aggressive Behavior and Marble Burying Behavior in Mice
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概要
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Behavioral effects of 5-{3-[((2S)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy}-1, 3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, were evaluated using animal models of anxiety and obsessive compulsive disorder and compared against reference compounds. MKC-242 suppressed foot shock-induced fighting behavior without loss of motor coordination in mice as the reference compounds did. The ED50 values of MKC-242, buspirone, tandospirone and diazepam were 1.7, 42, 80 and 2.0 mg/kg, p.o., respectively. The duration of the suppression of fighting by MKC-242 was longer than those of buspirone and tandospirone and comparable to that of diazepam. Similar results were also obtained with the water-lick conflict test in rats. The plasma concentration of MKC-242 in rats was much higher than the reported value of buspirone during 0.25 – 6 hr after oral administration. In addition, MKC-242 reduced marble burying behavior without reduction of motor activity. Fluoxetine, tandospirone and diazepam also reduced the behavior at non-sedative doses. These findings indicate that MKC-242 possesses a longer-lasting anxiolytic effect than azapirones. This might be due to the high concentration of the compound in plasma. In addition, it is also suggested that MKC-242 possesses an antiobsessional effect.
- 社団法人 日本薬理学会の論文
著者
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ABE Michikazu
Pharmacology Department IV, Mitsubishi Tanabe Pharma Co.
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SAITO Ken-ichi
Pharmaceuticals Laboratory, Research Center, Mitsubishi Kasei Co.
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Egawa Mitsuo
Clinical Research Department Mitsubishi Chemical Corporation
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Abe Michikazu
Pharmaceutical Laboratory I Yokohama Research Center Mitsubishi Chemical Corporation
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Abe Michikazu
Pharmaceuticals Laboratory I Yokohama Research Center Mitsubishi Chemical Corporation
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NAKAI Hiroshi
Pharmacokinetics and Drug Metabolism Laboratory Yokohama Research Center, mitsubishi Chemical Corpor
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TABATA Reiko
Pharmaceuticals Laboratory I, Yokohama Research Center, Mitsubishi Chemical Corporation
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Tabata Reiko
Pharmaceuticals Laboratory I Yokohama Research Center Mitsubishi Chemical Corporation
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Nakai Hiroshi
Pharmacokinetics And Metabolism Research Laboratory Yokohama Research Center Mitsubishi Chemical Cor
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Nakai Hiroshi
Pharmacokinetics And Drug Metabolism Laboratory Yokohama Research Center Mitsubishi Chemical Corpora
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Saito Ken-ichi
Pharmaceuticals Laboratory I Yokohama Research Center Mitsubishi Chemical Corporation
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