Possible Involvement of K_<ATP> Channel Activation in Depressor Responses to Vasoactive Neuropeptides in Rats

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概要

• 論文の詳細を見る

• I.v. bolus injections of vasoactive intestinal polypeptide (VIP) (0.3 or 1 μg/kg), calcitonin gene-related peptide (CGRP) (0.3 μg/kg) or substance P (0.1 μg/kg) to anesthetized rats reduced blood pressure, accompanied by slight increases in heart rate. Cromakalim (0.3 μg/kg/min) infused i.v. significantly potentiated the depressor responses to VIP and CGRP, but not those to substance P and acetylcholine (ACh) (0.1 μg/kg). Glibenclamide (20 mg/kg, i.v.) significantly inhibited not only the depressor responses to VIP and CGRP, but also the augmentation of the effects of the two agents by cromakalim. These results suggest that the depressor responses to VIP and CGRP are mediated in part through KATP channel activation.

• 社団法人 日本薬理学会の論文

著者

• Sakai Kazushige

  Central Research Laboratories Chugai Pharmaceutical Co. Ltd.

• Saito Keiji

  Central Research Laboratories Chugai Pharmaceutical Co. Ltd.

関連論文

• Effects of Nicorandil on Experimentally Induced Gastric Ulcers in Rats : A Possible Role of K_ Channels
• Possible Involvement of K_ Channel Activation in Depressor Responses to Vasoactive Neuropeptides in Rats

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