Cerebrovascular Inflammation Following Subarachnoid Hemorrhage

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概要

• 論文の詳細を見る

• Aneurysmal subarachnoid hemorrhage frequently results in complications including intracranial hypertension, rebleeding and vasospasm. The extravasated blood is responsible for a cascade of reactions involving release of various vasoactive and pro-inflammatory factors (several of which are purported to induce vasospasm) from blood and vascular components in the subarachnoid space. The authors review the available evidence linking these factors to the development of inflammatory lesions of the cerebral vasculature, emphasizing: 1) neurogenic inflammation due to massive release of sensory nerve neuropeptides; 2) hemoglobin from lysed erythrocytes, which creates functional lesions of endothelial and smooth muscle cells; 3) activity, expression and metabolites of lipoxygenases cyclooxygenases and nitric oxide synthases; 4) the possible role of endothelin-1 as a pro-inflammatory agent; 5) serotonin, histamine and bradykinin which are especially involved in blood-brain barrier disruption; 6) the prothrombotic and pro-inflammatory action of complement and thrombin towards endothelium; 7) the multiple actions of activated platelets, including platelet-derived growth factor production; 8) the presence of perivascular and intramural macrophages and granulocytes and their interaction with adhesion molecules; 9) the evolution, origins, and effects of pro-inflammatory cytokines, especially IL-1, TNF-α and IL-6. Human and animal studies on the use of anti-inflammatory agents in subarachnoid hemorrhage include superoxide and other radical scavengers, lipid peroxidation inhibitors, iron chelators, NSAIDs, glucocorticoids, and serine protease inhibitors. Many animal studies claim reduced vasospasm, but these effects are not always confirmed in human trials, where symptomatic vasospasm and outcome are the major endpoints. Despite recent work on penetrating vessel constriction, there is a paucity of studies on inflammatory markers in the microcirculation.

• 社団法人 日本薬理学会の論文
• 2002-03-01

著者

• Gomis Philippe

  Laboratoire De Recherches Cerebrovasculaires Cnrs Upr 646 Ifr Circulation Lariboisiere Universite Pa

• SERCOMBE Richard

  Laboratoire de Recherches Cerebrovasculaires, CNRS UPR 646, IFR Circulation Lariboisiere, Universite

• TRAN DINH

  Laboratoire de Recherches Cerebrovasculaires, CNRS UPR 646, IFR Circulation Lariboisiere, Universite

• Tran Dinh

  Laboratoire De Recherches Cerebrovasculaires Cnrs Upr 646 Ifr Circulation Lariboisiere Universite Pa

• Sercombe R

  Laboratoire De Recherches Cerebrovasculaires Cnrs Upr 646 Ifr Circulation Lariboisiere Universite Pa

• Sercombe Richard

  Laboratoire De Recherches Cerebrovasculaires

• Dinh Yves

  Laboratoire de Recherches Cerebrovasculaires, CNRS UPR 646, IFR Circulation Lariboisiere, Universite Paris VII

関連論文

• Cerebrovascular Inflammation Following Subarachnoid Hemorrhage
• Critical Role of Endothelial Nitric Oxide Synthase and Cyclooxygenase in Response of Rabbit Basilar Artery to Serotonin

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