Molecular Basis of Spatio-temporal Dynamics in Inositol 1,4,5-Trisphosphate-Mediated Ca^<2+> Signalling

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概要

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• Inositol 1, 4, 5－trisphosphate(IP<SUB>3</SUB>)－mediated Ca<SUP>2+</SUP> signalling regulates many important cell functions, and the spatio－temporal dynamics of the Ca<SUP>2+</SUP> signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca<SUP>2+</SUP> signalling are now being investigated, and I here describe the subtypes of IP<SUB>3</SUB> receptors that have distinct functional properties and contribute to the diversity of Ca<SUP>2+</SUP> signalling patterns.I also discuss the spatio－temporal dynamics of intracellular IP<SUB>3</SUB> concentration, describing recent methodological advances in monitoring intracellular IP<SUB>3</SUB> concentration.These findings highlight the potential importance of the spatio－temporal information of any signalling molecule.

• 公益社団法人 日本薬理学会の論文
• 2000-01-01

著者

• Iino M

  Dep. Of Pharmacology Graduate School Of Medicine The Univ. Of Tokyo

• Iino Masamitsu

  Department Of Pharmacology Graduate School Of Medicine The University Of Tokyo

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