Synthesis and Antibacterial Activity of α-Methylene-γ(β)-carboxy-γ-butyrolactones

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概要

• 論文の詳細を見る

• α-Methylene-γ(β)-carboxy-γ-butyrolactones (5 and 10) are considered to have strong antibacterial activity owing to large absolute electronegativity (χ), electron transfer(ΔΝ) and stabilization energy(ΔΕ) compared to potent cyclopentanone antibiotics. α-Methylene-γ-carboxy-γ-butyrolactone(5) was synthesized starting from L-glutamic acid and α-methylene-β-carboxy-γ-butyrolactone (α-methylene paraconic acid 10) was obtained via ethyl α-formylsuccinate(6) or hydroxymethylation of ethyl α-carbethoxysuccinate(11). α-Methylenationed 5 and 10 showed no strong antibacterial activity as we expected formerly.

• 日本油化学会の論文
• 2002-04-01

著者

• Tonari Kennosuke

  Course Of Indusrial Chemistry Kinki Polytechnic College

• Yonemoto Kenji

  Siraishi Kogyo Co. Ltd.

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• Structure and Antibacterial Activity of Cinnamic Acid Related Compounds
• Synthesis and Antibacterial Activity of α-Methylene-γ-alkylbutyrolactones
• Synthesis and Antibacterial Activity of α-Methylene-γ(β)-carboxy-γ-butyrolactones
• Synthesis and Antibacterial Activity of α-Methylenecamphor and Isophorone Derivatives

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