Sarcoidosis Associated with Acute Renal Failure and Increased Levels of Interleukin-6 in Urine

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概要

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• A 24-year-old man who had uveitis and showed intrathoracic lymph node swelling on a chest X-ray, was admitted to our hospital for further examination. Transbronchial lung biopsy specimens revealed non-caseating granulomas compatible to sarcoidosis. As the renal function became progressively worse, a specimen was obtained by renal biopsy. It showed a granuloma formation, and was diagnosed as renal sarcoidosis. A high level of interleukin(IL)-6 was detected in his urine. After oral administration of prednisolone, the renal function improved, and the urinary IL-6 level was reduced. These findings suggest that in sarcoidosis associated with renal failure, steroid therapy is effective and that IL-6 plays an important role in the pathogenesis of renal involvement of sarcoidosis.(Internal Medicine 37: 757-761, 1998)

• 社団法人 日本内科学会の論文

著者

• SONE Saburo

  The Third Department of Internal Medicine, Tokushima University School of Medicine

• Haku Takashi

  The Third Department Of Internal Medicine School Of Medicine Tokushima University

• Ogushi Fumitaka

  The Third Department Of Internal Medicine School Of Medicine Tokushima University

• Ohmoto Yasukazu

  Ohtsuka Pharmaceutical Co.

• MANIWA Koji

  The Third Department of Internal Medicine, School of Medicine, Tokushima University

• Maniwa Koji

  The Third Department Of Internal Medicine School Of Medicine Tokushima University

• Sone Saburo

  The Third Department Of Internal Medicine School Of Medicine Tokushima University

関連論文

• Symposium on Molecular Pathogenesis of Respiratory Diseases and Its Clinical Implication, Molecular Pathogenesis of Lung Cancer and Its Molecular Targeted Therapy
• An Autopsy Case of Cytokeratin 7-positive Minute Adenocarcinoma of the Lung with Systemic Metastases
• Sarcoidosis Associated with Acute Renal Failure and Increased Levels of Interleukin-6 in Urine

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