Changes in Lymphokine-activated Killer Activity in Peripheral Blood Lymphocytes from Canine Transmissible Venereal Sarcoma Models
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概要
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Time course changes in anti-tumor activity induced in peripheral blood lymphocytes (PBL) with recombinant human interleukin-2 (rhIL-2) and phytohemagglutinin-P (PHA) were studied in dogs implanted with canine transmissible venereal sarcoma (CTVS) as a tumor-bearing model. The rhIL-2-dependent and PHA-dependent cultures allowed selective proliferation of lymphocytes expressing Thy-1 antigens. The lymphocytes acquired a prolonged anti-tumor activity against the CTVS cells, starting from 2 weeks after the culture, indicating generation of lymphokine-activated killer (LAK) cells. The LAK cells showed serial growth in rhIL-2-containing culture medium for at least a further 2 weeks without loss of the anti-tumor activity.
- 社団法人 日本実験動物学会の論文
著者
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Fujinaga Toru
Department Of Veterinary Surgery Faculty Of Veterinary Medicine Hokkaido University
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Fujinaga Toru
Department Of Veterinary Clinical Science Graduate School Of Veterinary Medicine Hokkaido University
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MIZUNO Shinya
Department of Biological Sciences, Faculty of Fisheries, Hokkaido University
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KUROSAWA Tsutomu
The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch.
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Mizuno Shinya
Department Of Veterinary Surgery Faculty Of Veterinary Medicine Hokkaido University
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Kurosawa Tsutomu
The Institute Of Experimental Animal Sciences Osaka University Medical School
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