Activation of Background Membrane Conductance by the Tyrosine Kinase Inhibitor Tyrphostin A23 and Its Inactive Analog Tyrphostin A1 in Guinea Pig Ventricular Myocytes

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概要

• 論文の詳細を見る

• The effects of the tyrosine kinase (TK) inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 on background membrane conductance were investigated in guinea pig ventricular myocytes. TK-inhibiting A23 reversibly increased membrane conductance under conditions designed to minimize Na+, Ca2+, K+, and Na+-K+ pump currents. Similar stimulatory action was obtained with TK-inactive A1. The tyrphostin-induced current was inhibited by omitting external Na+ or Ca2+, suppressed by chelating internal Ca2+, blocked by external Cd2+ and Ni2+, and insensitive to changes in internal Cl− concentration. We conclude that tyrphostins have a direct, TK-independent action that increases membrane conductance probably by stimulating Na+-Ca 2+ exchange.

• 社団法人 日本薬理学会の論文
• 2001-11-01

著者

• Imanishi S

  Second Department Of Physiology Kanazawa Medical University

• Imanishi Sunao

  Second Department Of Physiology Kanazawa Medical University

• OGURA Toshitsugu

  Second Department of Physiology, Kanazawa Medical University

• SHIBAMOTO Toshishige

  Second Department of Physiology, Kanazawa Medical University

• Shibamoto Toshishige

  Second Department Of Physiology Kanazawa Medical University

• Ogura Toshitsugu

  Second Department Of Physiology Kanazawa Medical University

関連論文

• Osmometric and Water-Transporting Properties of Guinea Pig Cardiac Myocytes
• Activation of Background Membrane Conductance by the Tyrosine Kinase Inhibitor Tyrphostin A23 and Its Inactive Analog Tyrphostin A1 in Guinea Pig Ventricular Myocytes

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