Diallel Cross Analysis of Body Weight in Subspecies of Mice

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A complete 4 × 4 diallel cross of CF#1 (C), C57BL/6NCrj (B) C3H/HeNCrj (H) and Yonakuni wild mice (Y, Mus musculus molossinus yonakuni) has been conducted to estimate the effects of sex, degree of heterosis, general combining ability (gca), specific combining ability (sca), maternal ability, and reciprocal cross on body weight at 1(Wk1), 3 (Wk3), 6 (Wk6) and 10 (Wk10) weeks of age. A least squares analysis was performed on 828 mice and all sources of variation showed significant effects (P<0.01) on body weight but not sex at Wk1 (P>0.05). Males were heavier than females (P<0.01) at Wk3, Wk6 and Wk10. C and Y were the heaviest and lightest in body weight, whereas H and B were intermediate. Differences in body weight were observed between linebred and linecross at all ages studied: 6.57%, 10.22%, 8.70% and 5.89% heterosis for the respective ages. The degree of gca and maternal effects can be ranked as C>H>B>Y. Crossing between C and H had greater sca than other combinations at all ages studied, whereas B ¤ Y had the smallest. Mean body weight of the offspring from two-line reciprocal cross differed according to their dam. A relatively large proportion of additive genetic effects in contributing to the variation in offspring body weight was indicated.
社団法人　日本実験動物学会の論文
1999-10-01