Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats
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概要
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The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
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Akiyama Kayo
Institute Of Medical Science University Of Tsukuba
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Sutoo Den'etsu
Institute Of Medical Science University Of Tsukuba
関連論文
- Quantitative imaging of substance P in the human brain using a brain mapping analyzer
- Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats
- 1H-NMR studies of calmodulin: The modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.