Effect of TAK-637, a Tachykinin NK_1-Receptor Antagonist, on Lower Urinary Tract Function in Cats
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概要
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The effect of TAK-637 ((aR,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H[1,4]diazocino[2,1g][1,7]naphthyridine-6,13-dione), a tachykinin NK1-receptor antagonist, on lower urinary tract function was investigated in cats. TAK-637 (0.1, 0.3, 1 and 3 mg/kg, i.v.) produced a dose-dependent increase in bladder capacity without any significant reduction in voiding efficiency in decerebrate cats. The maximal increase in bladder capacity was 94%. By contrast, oxybutynin at 1 and 3 mg/kg (i.v.) produced a 18% and 35% increase in bladder capacity, respectively, with a 47% and 45% reduction in voiding efficiency. TAK-637 (3 mg/kg, i.v.) did not inhibit the micturition reflex induced by electrical stimulation of the rostral brainstem near the locus coeruleus, indicating that it does not impair the well-organized micturition reflex (bladder contraction and urethral relaxation). These results suggest that TAK-637 increases bladder storage capability without inhibiting the voiding function of the lower urinary tract, presumably by inhibiting the afferent pathway of the micturition reflex, rather than the efferent pathway.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
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Kamo Izumi
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Doi Takayuki
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
関連論文
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- Effect of TAK-637, a Tachykinin NK_1-Receptor Antagonist, on Lower Urinary Tract Function in Cats
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