Postprandial Hyperlipidemia in Zucker Diabetic Fatty fa/fa Rats, an Animal Model of Type II Diabetes, and Its Amelioration by Acyl-CoA:Cholesterol Acyltransferase Inhibition

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概要

• 論文の詳細を見る

• Postprandial hyperlipidemia (PH) is frequently observed in diabetic patients. We performed an oral fat-loading test in Zucker diabetic fatty (ZDF) fa/fa rats, a model for type II diabetes, to determine whether PH was induced in the rats. Post fat-loading changes in serum cholesterol and triglyceride levels were significantly greater in the fa/fa rats than those seen in their lean littermates and an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor significantly reduced these levels by 24% and 31%, respectively. Therefore, we confirmed that PH appeared in ZDF fa/fa rats by fat loading and ACAT inhibition may be a potential treatment for PH.

• 社団法人 日本薬理学会の論文
• 2001-05-01

著者

• Aragane Katsumi

  Central Research Laboratories Fujirebio Inc.

• Kusunoki Jun

  Central Research Laboratories Fujirebio Inc.

• FUJINAMI Koji

  Central Research Laboratories, Fujirebio Inc.

• KOJIMA Kazuhiro

  Central Research Laboratories, Fujirebio Inc.

• Fujinami Koji

  Central Research Laboratories Fujirebio Inc.

• Kojima Kazuhiro

  Central Research Laboratories Fujirebio Inc.

関連論文

• Postprandial Hyperlipidemia in Zucker Diabetic Fatty fa/fa Rats, an Animal Model of Type II Diabetes, and Its Amelioration by Acyl-CoA:Cholesterol Acyltransferase Inhibition

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