Involvement of Angiotensin II in Progression of Renal Injury in Rats With Genetic Non-insulin-Dependent Diabetes Mellitus (Wistar Fatty Rats)

スポンサーリンク

概要

• 論文の詳細を見る

• Wistar fatty (WF) rats have a genetic predisposition to hyperglycemia, polyuria, hyperinsulinemia, hyperlipidemia, obesity and nephropathy. These phenotypic characteristics are similar to those observed in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) nephropathy. In this study, the effects of two types of renin-angiotensin system inhibitors, an angiotensin II type 1-receptor antagonist (AT1A) and an angiotensin I-converting enzyme inhibitor (ACEI), on renal injury in WF rats were studied during the progressive phase of diabetic nephropathy. An AT1A, candesartan cilexetil (1 mg/kg), and an ACEI, enalapril (10 mg/kg), were administered orally once a day for 12 weeks, beginning when the rats were 27-week-old and already showed diabetic nephropathy and obesity. Both drugs prevented an increase in proteinuria during the experimental period. Furthermore, after 4-week intervention, the levels of proteinuria were markedly lower in drug-treated rats. At the end of the experiment, both drugs prevented the development of glomerular lesions without affecting glucose metabolism and obesity. In conclusion, the inhibition of angiotensin II activity ameliorated both existing proteinuria and the progression of proteinuria, resulting in preservation of glomerular structure. Thus angiotensin II plays important roles in the development and the progression of nephropathy in genetically obese diabetic WF rats.

• 社団法人 日本薬理学会の論文
• 2001-04-01

著者

• Ohta M

  Research Management Department Takeda Chemical Industries Ltd

• Imura Yoshimi

  Drug Safety Research Laboratories Pharmaceutical Research Division

• Naka Takehiko

  Pharmaceutical Discovery Research Division Takeda Chemical Industries Ltd

• MATSUO Takanori

  Pharmacology Research Laboratories II, Pharmaceutical Research Division

• SHIBOUTA Yumiko

  Research Management Department, Takeda Chemical Industries Ltd

• IMURA Yoshimi

  Pharmacology Research Laboratories II, Pharmaceutical Research Division

• NODA Masakuni

  Pharmacology Research Laboratories II

• NAGANO -

  Pharmacology Research Laboratories II

• OHTA Masayuki

  Pharmaceutical Discovery Research Division

• SEKIGUCHI Masahiro

  Drug Analysis & Pharmacokinetics Research Laboratories, Pharmaceutical Research Division

• Shibouta Yumiko

  Research Management Department Takeda Chemical Industries Ltd

• Matsuo Takanori

  Pharmacology Research Laboratories Ii Pharmaceutical Research Division

• Sekiguchi Masahiro

  Drug Analysis & Pharmacokinetics Research Laboratories Pharmaceutical Research Division

• Nagano-Tsuge Hiroko

  Pharmacology Research Laboratories II

• Matsuo Takanori

  Pharmacology Research Laboratories II

関連論文

• Basic Avoidance of Food Competition among Ruminants, Non-Ruminants and Humans -A Simple Analytic Description-
• Basic Dividing of Foods between Ruminants and Humans when based on the Production of Forages or Grain Crops,or Both -A Simple Analytic Description-
• Contrastive or Interconvertible Relationships between Forage and Ruminant Growth Analysis Equations-A Simple Description using a Symmetry-like Characteristic-
• Estimation of Light Intercepting Performance of Plant Canopy using Mean Leaf Area Weighted with Relative Light Intensity
• Renal Protective Effect of Candesartan Cilexetil in Spontaneously Hypercholesterolemic Rats
• Involvement of Angiotensin II in Progression of Renal Injury in Rats With Genetic Non-insulin-Dependent Diabetes Mellitus (Wistar Fatty Rats)
• Blockade of renin-angiotensin system ameliorates renal injury in NIDDM model rats

スポンサーリンク