Molecular Pharmacology of T-type Ca^<2+> Channels

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概要

• 論文の詳細を見る

• Over the past few years increasing attention has been focused on T-type calcium channels and their possible physiological and pathophysiological roles. Efforts toward elucidating the exact role(s) of these calcium channels have been hampered by the lack of T-type specific antagonists, resulting in the subsequent use of less selective calcium channel antagonists. In addition, the activity of these blockers often varies with cell or tissue type, as well as recording conditions. This review summarizes a variety of compounds that exhibit varying degrees of blocking activity towards T-type Ca2+ channels. It is designed as an aid for researchers in need of antagonists to study the biophysical and pathological nature of T-type channels, as well as a starting point for those attempting to develop potent and selective antagonists of the channel.

• 社団法人 日本薬理学会の論文
• 2001-04-01

著者

• MACDONALD Timothy

  Department of Chemistry, University of Virginia

• Perez -

  Department Of Pharmacology University Of Virginia

• HEADY Tiffany

  Department of Chemistry, University of Virginia

• GOMORA Juan

  Department of Pharmacology, University of Virginia

• Macdonald Timothy

  Department Of Chemistry University Of Virginia

• Gomora Juan

  Department Of Pharmacology University Of Virginia

• Heady Tiffany

  Department Of Chemistry University Of Virginia

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• Molecular Pharmacology of T-type Ca^ Channels

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