The Biological Role of Non-neuronal Acetylcholine in Plants and Humans

スポンサーリンク

概要

• 論文の詳細を見る

• Acetylcholine, one of the most exemplary neurotransmitters, has been detected in bacteria, algae, protozoa, tubellariae and primitive plants, suggesting an extremely early appearance in the evolutionary process and a wide expression in non-neuronal cells. In plants (Urtica dioica), acetylcholine is involved in the regulation of water resorption and photosynthesis. In humans, acetylcholine and/or the synthesizing enzyme, choline acetyltransferase, have been demonstrated in epithelial (airways, alimentary tract, urogenital tract, epidermis), mesothelial (pleura, pericardium), endothelial, muscle and immune cells (granulocytes, lymphocytes, macrophages, mast cells). The widespread expression of non-neuronal acetylcholine is accompanied by the ubiquitous expression of cholinesterase and acetylcholine sensitive receptors (nicotinic, muscarinic). Both receptor populations interact with more or less all cellular signalling pathways. Thus, non-neuronal acetylcholine can be involved in the regulation of basic cell functions like gene expression, proliferation, differentiation, cytoskeletal organization, cell-cell contact (tight and gap junctions, desmosomes), locomotion, migration, ciliary activity, electrical activity, secretion and absorption. Non-neuronal acetylcholine also plays a role in the control of unspecific and specific immune functions. Future experiments should be designed to analyze the cellular effects of acetylcholine in greater detail and to illuminate the involvement of the non-neuronal cholinergic system in the pathogenesis of diseases such as acute and chronic inflammation, local and systemic infection, dementia, atherosclerosis, and finally cancer.

• 社団法人 日本薬理学会の論文
• 2001-01-01

著者

• Kirkpatrick Charles

  Department Of Pathology University Of Mainz

• WESSLER Ignaz

  Department of Pharmacology, University of Mainz

• KILBINGER Heinz

  Department of Pharmacology, University of Mainz

• BITTINGER Fernando

  Department of Pathology, University of Mainz

• Bittinger Fernando

  Department Of Pathology University Of Mainz

• Kilbinger Heinz

  Department Of Pharmacology University Of Mainz

• Wessler Ignaz

  Department Of Pharmacology University Of Mainz

関連論文

• The Non-neuronal Cholinergic System in the Endothelium: Evidence and Possible Pathobiologiacal Significance
• The Biological Role of Non-neuronal Acetylcholine in Plants and Humans

スポンサーリンク