Effect of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression.

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概要

• 論文の詳細を見る

• The original publication is available at springerlink.comWe investigated effect of ursodeoxycholic acid on major histocompatibility complex class I gene expression in cultured human hepatoma cells. Ursodeoxycholic acid, which has recently been used for treatment of various autoimmune liver diseases, paradoxically increased mRNA level of major histocompatibility complex class I. However, endogenous bile acids, for example, chenodeoxycholic acid, more strongly increased major histocompatibility complex class I mRNA expression when compared with ursodeoxycholic acid. Concerning interplay between ursodeoxycholic acid and chenodeoxycholic acid, these bile acids additively induced major histocompatibility complex class I mRNA expression. In contrast, when total concentration of ursodeoxycholic acid and chenodeoxycholic acid was kept constant, expression of major histocompatibility complex class I mRNA appeared to be rather decreased in a dose-dependent manner along with increasing ratio of ursodeoxycholic acid. These data might indicate that the beneficial action of ursodeoxycholic acid is related to this relative decrease in major histocompatibility complex class I gene expression.

• 1996-02-01

著者

• MAKINO Isao

  Second Department of Internal Medicine, Asahikawa Medical College

• Okamoto K

  Second Department Of Internal Medicine Faculty Of Medicine Tottori University

• Makino Isao

  Second Department Of Internal Medicine Asahikawa Medical College

• Okamoto Kensaku

  The Second Department Of Internal Medicine Asahikawa Medical College

• Okamoto Kensaku

  Second Department Of Internal Medicine Asahikawa Medical College

• Tanaka H

  Second Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry Kyushu University

• HIRANO Fuminori

  Second Department of Internal Medicine, Asahikawa Medical College

• TANAKA Hirotoshi

  the Second Department of Internal Medicine, Asahikawa Medical College

• MAKINO Yuichi

  the Second Department of Internal Medicine, Asahikawa Medical College

• HIRANO Fuminori

  the Second Department of Internal Medicine, Asahikawa Medical College

• TANAKA Hirotoshi

  Second Department of Internal Medicine, Asahikawa Medical College

• MAKINO Yuichi

  Second Department of Internal Medicine, Asahikawa Medical College

• Hirano Fuminori

  Second Department Of Internal Medicine Asahikawa Medical College

• Makino Yuichi

  The Second Department Of Internal Medicine Asahikawa Medical College

• Tanaka Hirotoshi

  The Second Department Of Internal Medicine Asahikawa Medical College

• Makino I

  Second Department Of Internal Medicine Asahikawa Medical College

• 平野 史倫

  Second Department of Internal Medicine, Asahikawa Medical College

• Makino Y

  Second Department of Internal Medicine, Asahikawa Medical College

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