The First Japanese Case of Hb Santa Ana, an Unstable Abnormal Hemoglobin, Identified Rapidly by Electrospray Ionization Mass Spectrometry
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概要
- 論文の詳細を見る
Two members of a family had chronic hemolytic anemia due to unstable hemoglobin. The abnormal β-chain with a molecular weight of 16 u smaller than the normal β-chain was found within 5 minutes by analysis using electrospray ionization mass spectrometry. The substitution of amino acid was also determined rapidly by this new strategy. The leucine at the 88th position of the normal β-chain was substituted by proline in the hemoglobin as in Hb Santa Ana. This is the first report of a Japanese case of Hb Santa Ana; the clinical course was similar to that in the previously reported cases.(Internal Medicine 36: 365-370, 1997)
- 社団法人 日本内科学会の論文
著者
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Miyazaki Ayako
Kitasako Clinic
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SHIMIZU Akira
the Department of Clinical Pathology, Osaka Medical College
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Miyazaki Ayako
The Department Of Clinical Pathology Osaka Medical College
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Yonezawa Takeshi
The Ikeda City Hospital
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Nakanishi Toyofumi
The Department Of Clinical Pathology Osaka Medical College
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Shimizu A
Department Of Analytic Human Pathology Nippon Medical School
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KISHIKAWA Masahiko
the Department of Clinical Pathology, Osaka Medical College
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JOZAKI Kiyoshi
the Ikeda City Hospital
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Kishikawa Masahiko
The Department Of Clinical Pathology Osaka Medical College
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Shimizu Akira
The Department Of Clinical Pathology Osaka Medical College
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