Does the Presence of Serum Autoantibodies Influence the Responsiveness to Interferon-α2a Treatment in Chronic Hepatitis C?
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概要
- 論文の詳細を見る
The serum autoantibodies, antinuclear antibody, anti-DNA antibody, anti-smooth muscle antibody, antithyroglobulin antibody, antimicrosomal antibody, antimitochondrial antibody, rheumatoid factor and antibody to deoxyribonucleoprotein were measured at the baseline and on completion of interferon-α2a (IFN-α2a) treatment in chronic hepatitis C (CHC) patients who did not present with any autoimmune disease prior to treatment. Of the 57 patients examined, 27 spontaneously manifested at least one autoantibody. Only the prevalence of rheumatoid factor (26%) was significantly higher in the CHC patients than in the control subjects. There were no differences in the prevalence of the 8 autoantibodies examined between hepatitis C virus (HCV) genotypes, Ib and 2a/2b. Twenty-six patients responded to IFN-α2a. Subclinical hypothyroidism developed in two patients with elevated antithyroid antibody titers during treatment. No relationship was observed between changes in the status of autoantibodies and either response to IFN-α2a or HCV genotype. Irrespective of the HCV genotype, autoantibodies might be present in CHC patients before and during the IFN-α2a treatment. The presence of such antibodies does not represent a contraindication to the use of IFN-α2a in CHC patients not complicated by autoimmune diseases. Careful observations are necessary for CHC patients positive for antithyroid antibodies during the IFN-α2a treatment. Preexisting or newly developed autoantibodies do not necessarily predict a poor response to IFN-α2a.(Internal Medicine 36: 248-254, 1997)
- 社団法人 日本内科学会の論文
著者
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NISHIGAMI Takashi
Second Department of Pathology, Hyogo College of Medicine
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Kang Kyong
The Department Of Internal Medicine Kobe Asahi Hospital
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Sawada Koji
Second Department Of Surgery Hyogo College Of Medicine
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Sagayama Ken
Second Department Of Surgery Hyogo College Of Medicine
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Sugihara K
Tokyo Medical And Dnetal Univ.
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SHIMOYAMA TAKASHI
Department of Gastroenterology, Hyogo College of Medicine
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Nishigami Takashi
Second Department Of Pathology Hyogo College Of Medicine
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Shintani Shigeyuki
The Fourth Department Of Internal Medicine
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Sawada Koji
The Fourth Department Of Internal Medicine Hyogo College Of Medicine
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Wada Masaaki
Wada Clinic
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Kinugasa Akira
The Fourth Department Of Internal Medicine
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Shimoyama T
Department Of Hygiene Hirosaki University School Of Medicine
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Shimoyama Takashi
The Fifth Department Of Internal Medicien Tokyo Medical College Kasumigaura Hospital
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WADA Masaaki
the Fourth Department of Internal Medicine
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Sawada Koji
The Fourth Department Of Internal Medicine
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Sugihara Kenichi
Department Of Surgical Oncology Tokyo Medical And Dental University
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