Ethosuximide-Induced Lupus-Like Syndrome with Renal Involvement

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概要

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• A 20-year-old man developed fever and urinary abnormalities with positive antinuclear antibody (ANA) two months after the start of ethosuximide. A renal biopsy showed mild mesangial cell proliferation and cellular crescents predominantly occupying a vascular pole in 7 out of 80 (8.8%) glomeruli. In the arteriole, mainly in close proximity to the glomerulus, proliferation of smooth muscle cells and luminal narrowing were observed. Discontinuation of ethosuximide led to the disappearance of fever, ANA and urinary abnormalities. These findings are strongly suggestive of a causal relationship between ethosuximide and a lupus-like syndrome with peculiar renal involvement.(Internal Medicine 35: 587-591, 1996)

• 社団法人 日本内科学会の論文

著者

• TAKEDA Shin-ichi

  the Internal Medicine of Kurobe City Hospital

• TAKAZAKURA Eisuke

  the Internal Medicine of Kurobe City Hospital

• Koizumi Fumitomo

  Pathology Of Toyama Medical And Pharmaceutical University

関連論文

• Methylprednisolone Pulse Therapy in Two Clinical Types of Crescentic Glomerulonephritis
• Ethosuximide-Induced Lupus-Like Syndrome with Renal Involvement

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