Human TSC-22 Gene: No Association with Type 2 Diabetes
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概要
- 論文の詳細を見る
Objective In order to elucidate whether or not genetic variations of TSC-22 (TGF [transforming growth factor]-β-stimulated clone 22), which was originally identified as a TGF-β-responsive leucine zipper protein in murine osteoblastic cells, are associated with type 2 diabetes, the genomic organization of the human TSC-22 gene was determined and the association between its polymorphisms and type 2 diabetes was examined. Results The human TSC-22 gene spans approximately 5 kilobase pairs and is encoded in three exons. Two single nucleotide polymorphisms (SNPs) were identified in the coding region of the first exon, two other SNPs in the first intron, and one SNP in the putative promoter region. There were, however, no significant differences in the frequency of these polymorphisms between patients with type 2 diabetes and non-diabetic control subjects. Conclusion It is unlikely that the TSC-22 gene is a locus responsible for type 2 diabetes.(Internal Medicine 40: 993-997, 2001)
- 社団法人 日本内科学会の論文
著者
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KUBOTA Akira
the Department of Hematology, National Kyushu Medical Center
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TAKAHASHI Kenji
the Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital
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Kuroe Akira
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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Yamada Yuichiro
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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Seino Yutaka
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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SUGAWARA Fumiaki
the Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University
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SOMEYA Yoshimichi
the Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University
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IHARA Yu
the Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University
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Ihara Yu
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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Sugawara Fumiaki
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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Someya Yoshimichi
The Department Of Metabolism And Clinical Nutrition Graduate School Of Medicine Kyoto University
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Takahashi Kenji
The Department Of Gastroenterology Oita Kouseiren Tsurumi Hospital
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Kubota Akira
The Department Of Hematology National Kyushu Medical Center
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Takahashi Kenji
The Department Of Cardiovascular Surgery Aomori Rhousai Hospital
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Takahashi Kenji
The Department Of Internal Medecine Kurashiki Central Hospital
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