Distinct Effect of G-CSF on the Growth and Differentiation of Myeloid Progenitor Cells from Chronic Idiopathic Neutropenia

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概要

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• Chronic idiopathic neutropenia (CIN) is a disorder characterized by severe neutropenia and a maturational arrest of the neutrophil precursors in the bone marrow. We examined the effect of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the growth and maturation of the myeloid progenitor cells from a patient with CIN. The patients marrow cells showed poor colony forming activity, but a normal differentiating capacity to the stimulation with rhG-CSF, although they displayed a normal colony forming capacity in the presence of GM-CSF. Our observation indicates the distinct effect of rhG-CSF on the growth and maturation of the myeloid progenitors from a CIN patient.(Internal Medicine 34: 384-387, 1995)

• 社団法人 日本内科学会の論文

著者

• Morikawa Keiko

  The Departments Of Internal Medicine Shimane Medical University

• Oseko Fumimaro

  The Departments Of Internal Medicine Shimane Medical University

• OIWA Kanji

  the Departments of Surgery, Shimane Medical University

• KUBOTA Toshibumi

  the Departments of Surgery, Shimane Medical University

• MORIKAWA Shigeru

  the Departments of Pathology, Shimane Medical University

• NAKAMURA Teruhisa

  the Departments of Surgery, Shimane Medical University

• Nakamura Teruhisa

  The Departments Of Surgery Shimane Medical University

• Oiwa Kanji

  The Departments Of Surgery Shimane Medical University

• Morikawa Shigeru

  The Departments Of Pathology Shimane Medical University

• Kubota Toshibumi

  The Departments Of Surgery Shimane Medical University

関連論文

• Distinct Effect of G-CSF on the Growth and Differentiation of Myeloid Progenitor Cells from Chronic Idiopathic Neutropenia

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