Phospholipid-Dependent Anti-β_2-Glycoprotein I (β_2-GPI) Antibodies and Antiphospholipid Syndrome

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概要

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• A portion of anticardiolipin antibodies is defined as phospholipid-dependent anti-β2-glycoprotein I (β2-GPI) antibodies and recognizes the conformationally altered (β2-GPI which interacts with anionic phospholipids. We studied the clinical significance of IgG phospholipid-dependent anti-β2-GPI antibodies in patients with antiphospholipid syndrome (APS). The subjects consisted of 60 APS patients. IgG phospholipid-dependent anti-β2-GPI antibodies were detected by ELISA in 32 of the 60 patients (53%). Significantly higher incidences of prolonged APTT and lupus anticoagulants were found in patients with these anti-β2-GPI antibodies. Moreover, significantly lower incidences of malar rash, serositis, LE cell preparation and anti-Sm antibodies were found in patients with these anti-β2-GPI antibodies. It was found that 88% of the patients with these anti-β2-GPI antibodies satisfied less than five of the revised criteria items for the classification of SLE. These findings indicate the clinical characteristics of APS patients with IgG phospholipid-dependent anti-β2-GPI antibodies.(Internal Medicine 35: 105-110, 1996)

• 社団法人 日本内科学会の論文

著者

• KUWANA Masataka

  The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine

• KABURAKI Junichi

  The Department of Internal Medicine, Tokyo Electric Power Company Hospital

• Matsuura Eiji

  The Immunology Laboratory Yamasa Corp.

• Ikeda Yasuo

  Internal Medicine, Keio University School of Medicine

• Kuwana Masataka

  The Department Of Internal Medicine Keio University School Of Medicine

• YAMAMOTO Mihoko

  Laboratory Medicine Keio University School of Medicine

• KAWAI Shinichi

  the Institute of Medical Science, St. Marianna University School of Medicine

• Ikeda Yasuo

  Internal Medicine Keio University School Of Medicine

• Kawai Shinichi

  The Institute Of Medical Science St. Marianna University School Of Medicine

• Kaburaki Junichi

  The Department Of Internal Medicine Keio University School Of Medicine

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• Phospholipid-Dependent Anti-β_2-Glycoprotein I (β_2-GPI) Antibodies and Antiphospholipid Syndrome
• Clinical Features and Pathogenesis of Catastrophic Antiphospholipid Syndrome
• Anti-cardiolipin-β2-GPI Complex Antibodies in Idiopathic Thrombocytopenic Purpura
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