SPR Sensor as a Tool to Evaluate Binding Capacity of Gastric Ulcer Drugs with Mucous Membrane

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概要

• 論文の詳細を見る

• Covalent immobilization of mucin molecules was carried out on a gold surface of surface plasmon resonance sensor. Interaction of three types of gastric ulcer drug with mucin was detected by measuring the shift of resonance angle. The two gastric proton pump inhibitors have shown drastic change, while antagonist of histamine H2 receptor, showed insignificant change. The result suggests that SPR-based measurement is capable of evaluating binding capacity between an intestinal membrane and corresponding biosubstance, such as a gastric ulcer agent and mucin.

• 社団法人 電気学会の論文
• 2001-08-01

著者

• Yamauchi Shigeru

  National Rehabilitation Center For The Disabled

• Ikariyama Y

  National Rehabilitation Center For The Disabled

• Ikariyama Yoshihito

  National Rehabilitation Center For The Disabled

• Toyama S

  National Rehabilitation Center For The Disabled

• Toyama Shigeru

  National Rehabilitation Center For The Disabled

• Shoji Atsumu

  National Rehabilitation Center For The Disabled

• YOSHIDA Yasuhiko

  Toyo University

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• Glucose Sensor Based on Nickelocene Blended Carbon Paste Electrode--Suppression of Enzyme Leaking from Electrode Surface (特集 バイオセンサ)
• SPR Sensor as a Tool to Evaluate Binding Capacity of Gastric Ulcer Drugs with Mucous Membrane

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