Adult T-cell Leukemia
スポンサーリンク
概要
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Adult T-cell leukemia (ATL) was first reported in Japan, where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is the causative agent of ATL. In ATL-endemic areas, the rate of HTLV-I carriers is high. A definite diagnosis of ATL is based on the presence of HTLV-I proviral DNA in the tumor cell DNA. ATL cells originate from the CD4 subset of peripheral T cells. ATL shows diverse clinical features but can be divided into four subtypes: acute, chronic, smoldering, and lymphoma type. Chemotherapy is not effective; the acute and lymphoma types have a poor prognosis. Familial occurrence of ATL is common. HTLV-I infection is caused by transmission of live infected lymphocytes from mother to child, from man to woman, or by blood transfusion. Infection with HTLV-I can lead to other diseases, including HTLV-I-associated myelopathy/tropical spastic paraparesis and HTLV-I uveitis.(Internal Medicine 34: 947-952 1995)
- 社団法人 日本内科学会の論文
著者
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TAKATSUKI Kiyoshi
The Second Department of Internal Medicine, Kumamoto University School of Medicine
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Takatsuki Kiyoshi
The Second Department Of Internal Medicine Kumamoto University School Of Medicine
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Takatsuki Kiyoshi
The Second Department Of Internal Medicine And The Transfusion Service Department Kumamoto Universit
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