Calcitonin-Like Polypeptides without Apparent Biological Activity in a Patient with Recurrent Medullary Thyroid Carcinoma.
スポンサーリンク
概要
- 論文の詳細を見る
A 51-year-old male with a recurrent medullary thyroid carcinoma (MTC) showed high serum levels of calcitonin (CT) and carcinoembryonic antigen (CE A) but with concomitant normocalcemia. The CT activities of the patients serum in vivo (hypocalcemic activity in rats) and in vitro (cyclic AMP-increasing activity in cultured human mammary tumor, T47D) were much lower than those expected from the patients CT level. High performance liquid chromatography (HPLC) with radioimmunoassay (RIA) detection gave a broad spectrum of molecular weights of CT-like polypeptides in the 3 kDa to 200 kDa range with separation from CEA, suggesting that the mechanism for CT production in MTC is an obscure one.(Internal Medicine 34: 896-900, 1995)
- 社団法人 日本内科学会の論文
著者
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HANADA Masato
the Department of Pathology
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Minami Yuzo
The Department Of Internal Medicine Osaka Central Hospital.
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Hanada Masato
The Department Of Pathology Toyonaka Municipal Hospital
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Hirota Takashi
The Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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NAKAJIMA Katsuaki
the Department of Internal Medicine, Osaka Central Hospital.
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JINKAWA Izumi
the Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
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IKEDA Toshihiko
the Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
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TUGAWA Mamiko
the Department of Internal Medicine, Osaka Central Hospital.
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Tugawa Mamiko
The Department Of Internal Medicine Osaka Central Hospital.
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Jinkawa Izumi
The Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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Nakajima Katsuaki
The Department Of Internal Medicine Osaka Central Hospital.
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Ikeda Toshihiko
The Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
関連論文
- Synchronous Fluctuation of Interleukin-6 and Platelet Count in Cyclic Thrombocytopenia and Thrombocytosis
- Calcitonin-Like Polypeptides without Apparent Biological Activity in a Patient with Recurrent Medullary Thyroid Carcinoma.