Acute Myelomonocytic Leukemia in a Patient with Multiple Myeloma: Evidence for Different Clonal Origin
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概要
- 論文の詳細を見る
A case of 77-year-old female with multiple myeloma (IgG-k) developed acute myelomonocytic leukemia (AMMoL) following a myelodysplastic stage after chemotherapy with melphalan-cyclophosphamide combinations for 6 years. The leukemic blast cells expressed both myeloid antigens (CDllb, CD13, CD14, CD15, CD33 and CD34) and T/B lymphoid antigens (CD2, CD4, CD22 and PCA1). Cytogenetic analysis revealed a chromosome deletion -7. Analysis of immunoglobulin genes showed the heavy chain genes in germ line configuration. These findings indicate that the AMMoL was a therapy-related stem cell leukemia and was a clonal origin genetically different from multiple myeloma irrespective of plasma cell phenotype.(Internal Medicine 34: 546-549, 1995)
- 社団法人 日本内科学会の論文
著者
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Tsuji Kota
The Department Of Internal Medicine Yamada Red Cross Hospital
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TAMAKI Shigehisa
Department of Internal Medicine, Yamada Red Cross Hospital
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Tamaki Shigehisa
The Department Of Internal Medicine Yamada Red Cross Hospital
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Nakase Kazunori
The Department Of Internal Medicine Yamada Red Cross Hospital
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TANIGAWA Motoaki
Department of Internal Medicine, Yamada Red Cross Hospital
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MIYANISHI Eiki
Department of Internal Medicine, Yamada Red Cross Hospital
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HASEGAWA Masaki
the Department of Internal Medicine, Yamada Red Cross Hospital
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SUZUKI Yoshinori
the Department of Internal Medicine, Yamada Red Cross Hospital
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TANIGAWA Motoaki
the Department of Internal Medicine, Yamada Red Cross Hospital
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IKEDA Takeshi
the Department of Internal Medicine, Yamada Red Cross Hospital
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MIYANISHI Eiki
the Department of Internal Medicine, Yamada Red Cross Hospital
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Miyanishi Eiki
The Department Of Internal Medicine Yamada Red Cross Hospital
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Tanigawa Motoaki
The Department Of Internal Medicine Yamada Red Cross Hospital
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Hasegawa Masaki
The Department Of Internal Medicine Yamada Red Cross Hospital
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Ikeda Takeshi
The Department Of Internal Medicine Yamada Red Cross Hospital
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Suzuki Yoshinori
The Department Of Internal Medicine Yamada Red Cross Hospital
関連論文
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- Acute Myelomonocytic Leukemia in a Patient with Multiple Myeloma: Evidence for Different Clonal Origin
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