Selective Inhibition of Inducible Nitric Oxide Synthase by Agmatine

スポンサーリンク

概要

• 論文の詳細を見る

• Agmatine was about as potent as aminoguanidine to inhibit the activity of the inducible form of nitric oxide synthase (iNOS) in isolated rat aorta. Like aminoguanidine, agmatine was devoid of significant activity on the constitutive form of NOS. Agmatine inhibited the conversion of [<SUP>3</SUP>H]L-arginine in [3H]L-citrulline in partially purified iNOS from macrophages (IC<SUB>50</SUB>=262±39.9 μM). Thus, our data suggest that agmatine may act as endogenous inhibitor of iNOS.

• 社団法人 日本薬理学会の論文
• 1995-11-01

著者

• Chabrier Pierre-etienne

  Institut Henri Beaufour Research Laboratories Za De Courtaboeuf

• AUGUET Michel

  Institut Henri Beaufour Research Laboratories, ZA de Courtaboeuf

• VIOSSAT Isabelle

  Institut Henri Beaufour Research Laboratories, ZA de Courtaboeuf

• MARIN Jean-Gregoire

  Institut Henri Beaufour Research Laboratories, ZA de Courtaboeuf

• Viossat Isabelle

  Institut Henri Beaufour Research Laboratories Za De Courtaboeuf

• Marin Jean-gregoire

  Institut Henri Beaufour Research Laboratories Za De Courtaboeuf

• Auguet Michel

  Institut Henri Beaufour Research Laboratories Za De Courtaboeuf

関連論文

• Selective Inhibition of Inducible Nitric Oxide Synthase by Agmatine

スポンサーリンク