Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP - 4819, on Thyrotropin - Releasing Hormone - Like Immunoreactivity in the Cerebral Cortex and Hippocampus of Aged Rats

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概要

• 論文の詳細を見る

• We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((<I>S</I>)-2-[[(<I>S</I>)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-<I>N</I>-(phenylmethyl)-1-pyrrolidinecarboxamide), on thyrotropin-releasing hormone (TRH)-like immunoreactivity (TRH-LI) in the cerebral cortex and hippocampus of aged rats. The TRH-LI content of both brain regions in aged rats was significantly lower than that in young rats. A single oral dose of JTP-4819 (3 mg/kg) restored the cortical TRH-LI content in aged rats, while doses of 0.3-3 mg/kg restored it in the hippocampus. Repeated oral administration of JTP-4819 at a dose of 1 mg/kg for 21 days produced a significant increase of TRH-LI in the cerebral cortex, while it did so in the hippocampus at doses of 0.3 and 1 mg/kg. Our findings suggest that JTP-4819 may improve the functioning of TRHergic neurons, which deteriorate with senescence.

• 社団法人 日本薬理学会の論文
• 1995-11-01

著者

• Toide Katsuo

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• Shinoda Masahiko

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• OKAMIYA Kazuhiro

  Central Pharmaceutical Research Institute, Japan Tobacco Inc.

• Okamiya Kazuhiro

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

関連論文

• Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP - 4819, on Thyrotropin - Releasing Hormone - Like Immunoreactivity in the Cerebral Cortex and Hippocampus of Aged Rats

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