Phosphatidylserine-mediated phagocytosis of anticancer drug-treated cells by macrophages
スポンサーリンク
概要
- 論文の詳細を見る
Apoptotic cells are rapidly phagocytosed and eliminated from the organism. Although cancer cells apoptose when treated with anticancer drugs, how those cells are recognized by phagocytic cells has remained unclear. The human leukemia cell line Jurkat was cultured with doxorubicin or bufalin and induced to undergo apoptosis accompanied by phosphatidylserine externalization. When apoptotic Jurkat cells were mixed with mouse peritoneal macrophages, efficient phagocytosis was observed. Apoptosis and phagocytosis of Jurkat cells were both inhibited by Z-VAD-FMK, and phagocytosis was significantly reduced in the presence of phosphatidylserine-containing liposomes. These results suggest that anticancer drugs induce apoptosis- dependent and phosphatidylserine-mediated phagocytosis in cancer cells.
- 日本生化学会 = Japanese Biochemical Societyの論文
- 1999-12-01
著者
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Shiratsuchi Akiko
Faculty Of Pharmaceutical Sciences Kanazawa University
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Nakanishi Yoshinobu
Faculty Of Pharmaceutical Sciences Kanazawa University
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Nakanishi Yoshinobu
Faculty Of Pharmaceuical Science Kanazawa Unicersity
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