Betaxolol, a β_1 -Adrenoceptor Antagonist, Inhibits Ca^<2+>-Induced Contraction in Skinned Renal Artery of the Dog

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概要

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• The effects of betaxolol on Ca<SUP>2+</SUP>-induced contractions in saponin-treated skinned canine renal arteries were examined. Betaxolol decreased the pCa (-log[Ca<SUP>2+</SUP>] M) 5.8-induced contraction at the same concentrations at which the drug relaxed the high K<SUP>+</SUP>-induced contraction in intact smooth muscles. The pCa-tension relation was shifted to the right and downward by betaxolol. Betaxolol inhibited the increase in Cat+-induced contraction by calmodulin, and this effect of betaxolol was observed even at the concentration that had no effect when given alone. These results suggest that betaxolol decreases the Ca<SUP>2+</SUP> sensitivity of the contractile system in skinned canine renal arteries, presumably by inhibiting calmodulinmediated contractions.

• 社団法人 日本薬理学会の論文
• 1996-02-01

著者

• Kitada Yoshimi

  Pharmaceutical Laboratory I Yokohama Research Center Mitsubishi Chemical Corporation

関連論文

• Betaxolol, a β_1 -Adrenoceptor Antagonist, Inhibits Ca^-Induced Contraction in Skinned Renal Artery of the Dog
• Comparison of the Effects of MCI-154, a New Cardiotonic Agent, and Some Ca2+-Sensitizing Agents on the Response of the Contractile System to Ca2+ in Skinned Cardiac Muscle
• In vitro characterization of the effects of MCI-154, anovel cardiotonic agent, on cardiac tissues.
• Effects of betaxolol on cardiohemodynamics and coronary circulation in anesthetized dogs: Comparison with atenolol and propranolol.

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