Mixed genotype を示すC型慢性肝疾患に対するインターフェロ治療

概要

論文の詳細を見る
Of 83 patients with chronic hepatitis C who were treated with interferon (IFN), 32 patients (39%) showed the clearance of HCV RNA from serum at six months after the completion of IFN (responder). Response to IFN occurred in 14 (74%) of 19 patients infected with HCV genotype III/2a and in 6 (50%) of 12 with genotype IV/2b, more frequently than in 10 (20%) of 47 with genotype II/1b (p<0.001, p<0.05).<BR>There were 4 patients who were infected with two HCV strains of different genotypes (II/1b+III/2a, 2 patients, II/1b+IV/2b, 2 patients). One of these 4 patients with mixed genotype responded to IFN. Titers of total and genotype-specific HCV RNA were followed subsequently in serum from these 4 patients. The decrease in HCV RNA titers was observed irrespective of HCV genotypes, as a result, antiviral effect seemed to appear stronger to minor genotype than to major genotype in patients with chronic hepatitis C who were infected with mixed genotypes.
社団法人日本肝臓学会の論文
1995-05-25