ウイルス性慢性肝炎における肝内好酸球浸潤の病理組織学的検討-薬剤性肝障害との比較検討を含めて-
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概要
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Intrahepatic infiltration of eosinophils in liver biopsies from 144 cases with chronic viral hepatitis (88 cases of hepatitis C virus and 56 cases of hepatitis B virus), 35 cases with drug induced liver injury (DLI), 30 cases with acute viral hepatitis (AH) and 31 controls were analyzed. Intrahepatic infiltraion of eosinophils occurred mainly in portal areas, thus we studied eosinophilic infiltration ratio (EIR: total numbers of eosinophilis in portal areas per total numbers of portal areas in the entire specimen) statistically. The data obtained from the present sutyd are showed that EIR in patients with chronic viral hepatitis (patients with both HCV and HBV, or with either one) was increased compared with those DLI, AH and controls. Also, in patients with HCV, EIR increased in proportion with the increase of piecemeal necrosis and portal inflammation. This study also indicates that infiltration of eosinophils in portal areas was not related to liver fibrosis, and there was no significant difference in EIR level among patients with DLI, AH and controls.
- 社団法人 日本肝臓学会の論文
- 1996-01-25