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Department of Cardiovascular Surgery and Internal Medicine, Saiseikai Shimonoseki General Hospital | 論文
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
- Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
- Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
- O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids
- Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry
- Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
- Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
- Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
- Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
- Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
- Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
- Coronary spasm as a cause of perioperative myocardial infarction.