Idei Naomi | Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
スポンサーリンク
概要
- IDEI Naomiの詳細を見る
- 同名の論文著者
- Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciencesの論文著者
関連著者
-
Hidaka Takayuki
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Idei Naomi
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Fujii Yuichi
Department Of Cardiology
-
Higashi Yukihito
Department Of Cardiovascular Physiology And Medicine
-
FUJII Yuichi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Hata Takaki
Department Of Cardiology Hiroshima City Hospital
-
Soga Junko
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
HATA Takaki
Department of Cardiology, Hiroshima City Hospital
-
IDEI Naomi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Higashi Yukihito
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
SOGA Junko
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Nishioka Kenji
Department Of Anesthesiology Nagasaki University School Of Medicine
-
Nishioka Kenji
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Nishioka Kenji
Department Of Cardiovascular Medicine Hiroshima University
-
Nakamura Shuji
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Nishioka Kenji
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
-
Nakamura Syuji
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biochemical Sciences
-
Kihara Yasuki
Department Of Cardiology Graduate School Of Medicine Kyoto University
-
Fujimura Noritaka
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Higashi Yukihito
Department Of Molecular Internal Medicine Graduate School Of Biomedical Science Hiroshima University
-
Yoshimura Mitsuisa
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Yoshizumi Masao
Division Of Cardiology Cardiovascular Center Akane Foundation Tsuchiya General Hospital
-
FUJIMURA Noritaka
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
YOSHIZUMI Masao
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
-
Hayashi Yasuhiko
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Yoshizumi Masao
Department Of Cardiovascular Physiology And Medicine
-
Hirai Yuukou
Division Of Cardiology Akane Foundation Tsuchiya General Hospital
-
Yoshizumi Masao
Cardiovascular Center Tsuchiya General Hospital
-
Yoshimura Mitsuisa
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Masaoka Yoshiko
Cardiovascular Center Tsuchiya General Hospital
-
Hirai Yukoh
Department Of Internal Medicine Graduate School Of Biomedical Science Hiroshima University
-
Yoshizumi Masao
Department Of Cardiovascular Phisiology Graduate School Of Medicine Hiroshima University
-
Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
Yoshida Masashi
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Kihara Yasuki
Departments Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Kihara Yasuki
Department Of Cardiovascular Medicine Hiroshima University Hospital
-
Yoshimura Mitsuisa
From The Division Of Cardiology Hiroshima City Hospital
-
Takemoto Hiroaki
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima Univ
-
Chayama Kazuaki
Deparmtment Of Gastroenterology Toranomon Hospital
-
Nishioka Kenji
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Yoshimura Mitsuisa
First Department Of Internal Medicine Hiroshima University School Of Medicine
-
Takemoto Hiroaki
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Takemoto Hiroaki
Department Of Cardiology Hiroshima City Asa Hospital
-
Nakamura Shuji
Department Of Research And Development Nichia Chemical Industries Ltd.
-
Kato Yukio
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Hayashi Yasuhiko
Division Of Cardiology Cardiovascular Center Akane Foundation Tsuchiya General Hospital
-
Hirai Yukoh
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
-
TERAGAWA Hiroki
Department of Cardiology, Himeji Cardiovascular Center
-
NAKAMURA Shuji
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
-
Chayama Kazuaki
The First Department Of Internal Medicine Hiroshima University School Of Medicine
-
Teragawa Hiroki
Department Of Cardiovascular Medicine Hiroshima General Hospital Of West Japan Railway Company
-
Chayama Kazuaki
Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima Univer
-
Chayama Kazuaki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Chayama Kazuaki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Chayama Kazuaki
Department of Medicine and Molecular Biology, Hiroshima University School of Medicine
-
Teragawa Hiroki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
Chayama Kazuaki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Teragawa Hiroki
Hiroshima - CT Angiography Research Project (H-CARP) Group
-
Teragawa Hiroki
Department Of Cardiovascular Medicine Hiroshima University
-
Yoshizumi Masao
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Science Hiroshima
-
Yoshizumi Masao
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
-
Noma Kensuke
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Oshima Tetsuya
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Ohshima Tetsuya
First Department Of Internal Medicine Hiroshima University School Of Medicine
-
Gotoh Chikara
Department of Cardiovascular Physiology and Medicine, Hiroshima Univer
-
Goto Chikara
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Teragawa Hiroki
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biochemical Sciences
-
Oshima Tetsuya
The First Department Of Internal Medicine Hiroshima University School Of Medicine
-
Oshima Tetsuya
Department Of Clinical Medicine Graduate School Of Medicine Hiroshima University
-
Teragawa Hiroki
Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima Univer
-
UMEMURA Takashi
Department of Veterinary Clinical Science, Graduate School of Veterinary Medicine, Hokkaido Universi
-
Ooshima Tetsuya
Department of Clinical Laboratory and Medicine, Graduate School of Biomedical Sciences, Hiroshima Un
-
Umemura Takashi
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Noma Kensuke
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Teragawa Hiroki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Noma Kensuke
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Umemura Takashi
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Noma Kensuke
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
Umemura Takashi
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
-
NOMA Kensuke
Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomed
-
Hayashi Yasuhiko
Division Of Cardiology Department Of Medicine Hiroshima Akanekai Tsuchiya Hospital
-
Higashi Yukihito
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
YAMAMOTO Hideya
Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University
-
Nakano Yukiko
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
Nakamura Hideshi
Department of Cardiology, Hiroshima City Hospital
-
Okada Takenori
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
HIGASHI Yukihito
Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomed
-
Yamamoto Hideya
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Tadehara Futoshi
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biochemical Sciences
-
Ishida Takafumi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biochemical Sciences
-
Tadehara Futoshi
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Science
-
Tadehara Futoshi
Division Of Cardiology Mazda Hospital Hiroshima Prefecture
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
-
Yamamoto Hideya
Hiroshima - CT Angiography Research Project (H-CARP) Group
-
Nakano Yukiko
Department Of Cardiology Hiroshima University School Of Medicine
-
Nakagawa Keigo
Syoubara red cross hospital
-
Ishida Takafumi
Departments Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Ishida Takafumi
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
-
Tadehara Futoshi
Department Of Molecular And Internal Medicine Hiroshima University
-
Nakagawa Keigo
Syobara Red Cross Hospital
-
Maruhashi Tatsuya
Department Of Cardiology Hiroshima City Hospital
-
Okada Takenori
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biochemical Sciences
-
Okada Takenori
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Science
-
Nakano Yukiko
Department Of Biostructural Science Graduate School Of Tokyo Medical And Dental University
-
Nakano Yukiko
Department Of Clinical Laboratory Medicine Hiroshima University School Of Medicine
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University
-
Mikami Shinsuke
Department Of Cardiology Matsue Red Cross Hospital
-
Tadehara Futoshi
Department Of Cardiology Kure Kyosai Hospital
-
Nakamura Hideshi
Department Of Medicine And Morecular Science Graduate School Of Biomwdical Sciences Hiroshima Univer
-
Okada Takenori
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
-
Nakamura Hideshi
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
-
Nakano Yukiko
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Ishida Takafumi
Department Of Anthropology Faculty Of Science The University Of Tokyo
-
Tadehara Futoshi
Department Of Cardiology Mazda Hospital Mazda Motor Corporation
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
-
Ishida Takafumi
Department Of Cardiovascular Medicine Hiroshima University
-
Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
-
Iwamoto Yumiko
Department Of Cardiology Hiroshima Prefectural Hospital
-
Nakashima Ayumu
Division of Regeneration and Medicine, Hiroshima University Hospital
-
Goto Chikara
Hiroshima International University
-
Makita Yuko
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
OSHIMA Tetsuya
Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine
-
TAGUCHI Akira
Department of Oral and Maxillofacial Radiology, School of Dentistry, Hiroshima University
-
KIMURA Masashi
Department of Earth and Space Science, Osaka University
-
MITSUBA Naoya
Department of Cardiology, Hiroshima City Hospital
-
Tadehara Futoshi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
-
LIAO James
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School
-
Nishioka Kenji
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biochemical Sciences
-
Makita Yuko
Department Of Cardiology Hiroshima University School Of Medicine
-
Makita Yuko
Department Of Cardiology Hiroshima Prefectural Hospital
-
Kimura Masashi
Department Of Cardiology Toyohashi Heart Center
-
Kimura Masashi
Department Of Cardiovascular Physiology And Medicine Hiroshima University School Of Medicine
-
Mitsuba Naoya
Department Of Cadiovascular Medicine Hiroshima Univeristy Graduate School Of Biomedical Sciences
-
Sugiura Masaki
Saraya Co. Ltd
-
Cyayama Kazuaki
Department of Medicine and Molecular Science, Division of Frontier Medicine Science, Programs for Bi
-
SHINGU Tetsuji
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Bio
-
NAKATA Atsunori
Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University
-
OKUHARA Koichiro
Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University
-
WATARI Yuichiro
Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University
-
Watari Yuichirou
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Itarashiki Tomomasa
SARAYA CO., LTD
-
Kato Hitoshi
TENNOZU CLINIC
-
Noma Kensuke
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School
-
Mikami Shinsuke
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Jitsuiki Daisuke
Syobara Red Cross Hospital
-
Liao James
Vascular Medicine Research Unit Brigham And Women's Hospital And Harvard Medical School
-
Liao James
Vascular Medicine Research Brigham & Women's Hospital Harvard Medical School
-
Watari Yuichiro
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Higashi Yukihito
Division Of Cardiology Cardiovascular Center Akane Foundation Tsuchiya General Hospital
-
Taguchi Akira
Department Of Electrical And Electronic Engineering Musashi Institute Of Technology
-
Taguchi Akira
Department Of Oral And Maxillofacial Radiology Hiroshima University
-
Shingu Tetsuji
Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima Univer
-
Shingu Tetsuji
Department Of Medicine And Molecular Science Hiroshima University
-
Okuhara Koichiro
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Chayama Kazuaki
Department Of Medicine And Molecular Science Hiroshima University Graduate School Of Biomedical Scie
-
Itarashiki Tomomasa
Saraya Co. Ltd
-
Jitsuiki Daisuke
Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi
-
Nakamura Hideshi
Department Of Medicine And Morecular Science Graduate School Of Biomwdical Sciences Hiroshima Univer
-
Okuhara Koichiro
Dept. Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima University
-
Nakata Atsunori
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
-
Taguchi Akira
Department Of Applied Chemistry School Of Engineering The University Of Tokyo
-
Kimura Masashi
Department Of Medicine And Molecular Science Graduate School Of Biomedical Sciences Hiroshima University
-
Maruhashi Tatsuya
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Teragawa Hiroki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
-
Noma Kensuke
Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
-
Watari Yuichiro
Department of Cardiology, Hiroshima Prefectural Hospital, Japan
-
HIGASHI Yukihito
Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
著作論文
- Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers
- OE-175 Low-intensity Pulsed Ultrasound (LIPUS) Enhanced Angiogenesis in a Rat Hind Limb Ischemia Model, VEGF-A Expression and Mobilization in HUVEC(OE30,Preventive Medicine/Epidemiology/Education (H),Oral Presentation (English),The 73rd Annual Scientific
- Classification of Corkscrew Collaterals in Thromboangiitis Obliterans (Buerger's Disease) : Relationship Between Corkscrew Type and Prevalence of Ischemic Ulcers
- Acute Myocardial Infarction, in which the Culprit Lesion was within the Stented Portion, occurring Nine Years after Implantation of a Bare Metal Stent
- PJ-553 Classification of Corkscrew Collaterals in Thromboangitis Obliterans (Buerger's Disease) Using an Ultrasonography(Peripheral circulation/Vascular disease(08)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- PE-503 Relationship between the Number of Circulating Endothelial Progenitor Cells and Medical History of Cardiovascular Diseases(Atherosclerosis, clinical(08)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-160 Smoking Abolishes Ischemic Preconditioning-induced Augmentation of Endothelium-Dependent Vasodilation : Role of Endothelium-Derived Nitric Oxide and Endothelial Progenitor Cells(Atherosclerosis, clinical(05)(IHD),Poster Session(English),The 72nd An
- PE-118 Autologous Bone-Marrow Mesenchymal Stem Cell Implantation Induces Angiogenesis and Improves Endothelial Function in a Rabbit Ischemic Limb Model(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeti
- OJ-205 Aging and Hypertension Are Independent Risk Factors for Reduced Number of Circulating Endothelial Progenitor Cells(Hypertension, clinical(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-329 Periodontitis is Associated with Endothelial Dysfunction in Healthy Subjects as Well as Hypertensive Patients(Hypertension, clinical(02)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-748 Smoking Decreases the Number of Endothelial Progenitor Cells in Healthy Subjects but not in Patients with Cardiovascular Diseases(PJ126,Smoking/Alcohol/Life Style (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circ
- PJ-723 ACE Inhibitor Imidapril versus ARB Valsaratan on Endothelial Function in Patients with Essential Hypertension(PJ121,Hypertension, Clinical 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-718 The Effect of Selective Mineralocorticoid Receptor Blocker Eplerenone on Endothelial Function in Patients with Essential Hypertension(PJ121,Hypertension, Clinical 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- PJ-665 Periodontitis, Oral Infection-Inflammatory Pathway, is a Risk Factor for Endothelial Dysfunction in Patients with Coronary Artery Disease(PJ112,Atherosclerosis (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific
- PJ-442 A Combination Tablet of Losartan/Hydrochlorothiazide, PREMINENT[○!R], Improves Endothelial Function in Patients with Essential Hypertension(PJ075,Hypertension, Clinical 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japan
- PE-424 Age and Baseline Vascular Brachial Artery Diameter are Independent Predictors of Flow-mediated Vasodilation in Healthy Subjects(PE071,Echo/Doppler (Peripheral/Vascular) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese
- PE-153 Activation of Rho Kinase (ROCK) Leads to Left Ventricular Diastolic Function in Patients with Essential Hypertension(PE026,Cardiac Function (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- OE-391 Increased Leukocyte Rho Kinase (ROCK) Activity and Endothelial Dysfunction in Cigarette Smokers(OE66,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- OE-340 Rho Kinase Activity is Associated with Left Ventricular Hypertrophy in Hypertensive Patients(OE58,Hypertension, Clinical 2 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-058 Pioglitazone Improves Endothelial Function in Hypertensive Patients with Impaired Glucose Tolerance : Role of AMPK-eNOS pathway(New Insights into Metabolic Syndrome(02)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanes
- Classification of Corkscrew Collaterals in Thromboangiitis Obliterans (Buergers Disease) : – Relationship Between Corkscrew Type and Prevalence of Ischemic Ulcers –
- Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease
- Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease