Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy
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概要
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A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.
- 2012-01-15