Biochemical characterization of the very long-chain fatty acid elongase ELOVL7
スポンサーリンク
概要
- 論文の詳細を見る
Very long-chain fatty acids (VLCFAs) have a variety of physiological functions and are related to numerous disorders. The key step of VLCFA elongation is catalyzed by members of the elongase family, ELOVLs. Mammals have seven ELOVLs (ELOVL1-7), yet none of them has been purified and analyzed. In the presented study we purified ELOVL7 and measured its activity by reconstituting it into proteoliposomes. Purified ELOVL7 exhibited high activity toward acyl-CoAs with C18 carbon chain length. The calculated Km values toward C18: 3-CoA(n-3) and malonyl-CoA were both in the μM range. We also found that progression of the VLCFA cycle enhances ELOVL7 activity.
- 2011-10-20
論文 | ランダム
- 217 子宮頸部上皮内癌と微小浸潤扁平上皮癌との細胞像の比較検討(第41回日本臨床細胞学会秋期大会)
- 乳腺Adenomyoepitheliomaの1例
- 術前診断が困難であった肺Carcinoidの1例
- 乳腺Invasive micropapillary carcinomaの1例
- 体腔液中に出現したバーキットリンパ腫の1例