Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy
スポンサーリンク
概要
- 論文の詳細を見る
Dioxin-like compounds are endocrine disruptors. The effects of prenatal exposure to environmental levels of dioxins on immune function during infancy have not been clarified, although dioxins induce immunosuppression in offspring of animals. Moreover, human studies have not assessed the effects of gender- or congener-specific differences. The purpose of this study was to investigate the association between dioxin levels in maternal blood and the risk of infection and allergies in infancy. We examined 364 mothers and their infants enrolled in a Hokkaido Study on Environment and Children's Health between 2002 and 2005 in Sapporo, Japan. Relevant information was collected from a baseline questionnaire during pregnancy, medical records at delivery, and a follow-up questionnaire when the child was 18 months of age that assessed development of allergies and infections in infancy. Dioxin-like compound levels in maternal blood were measured with high-resolution gas chromatography/high-resolution mass spectrometry. Relatively higher levels of polychlorinated dibenzofuran were associated with a significantly increased risk of otitis media, especially among male infants (odds ratio=2.5, 95% confidence interval=1.1-5.9). Relatively higher levels of 2,3,4,7,8-pentachlorodibenzofuran were also associated with a significantly increased risk of otitis media (odds ratio=5.3, 95% confidence interval=1.5-19). However, we observed a weak association between dioxin-like compound levels and allergic symptoms in infancy. At environmental levels, prenatal exposure to dioxin-like compounds may alter immune function and increase the risk of infections in infancy, especially among males. The compound 2,3,4,7,8-pentachlorodibenzofuran may be responsible for this.
論文 | ランダム
- 21242 浮き上がりを生じる多層建築物の地震応答に関する模型振動台実験 : その1 試験体及び自由振動(振動実験 (2), 構造II)
- 21392 実測及び設計情報に基づくヘルスモニタリングシステムの概要(ヘルスモニタリング(1),構造II)
- 21446 高知能建築構造システムに関する日米共同構造実験研究 : (その72)大型試験体損傷検出実験におけるパラメータ同定とモデル化(高知能建築構造システム(2),構造II)
- 21445 高知能建築構造システムに関する日米共同構造実験研究 : (その71)大型試験体に組み込んだHPFRCC応答制御要素のQ-δ関係(高知能建築構造システム(2),構造II)
- 複数モードの固有振動数変化を用いた多層建築物の層損傷検出