[Reviews] Pathogenetic and clinical significance of genetic abnormalities in acute myeloid leukemia
スポンサーリンク
概要
- 論文の詳細を見る
[Abstract] Acute myeloid leukemia (AML) is a clonal disorder that is caused by acquired somatic mutations in hematopoietic stem/progenitors. These mutations mainly include chromosomal translocations and point mutations, which were divided into two major groups called Class I and Class II mutations. Class I mutations including those of FLT3, KIT, and RAS, which primarily promote the growth and survival of hematopoietic cells without significant effects on differentiation. Class II mutations include those of CBF, RARA, CEBPA, and MLL, which cause differentiation arrest or are involved in self-renewal of hematopoietic cells, while they hardly affect the growth and survival of hematopoietic cells. Thus, the cooperation between class I mutation and class II mutation is supposed to be required to develop AML. The screening of these genetic mutations is now performed to diagnose AML in daily clinical practice. In addition, because these abnormalities crucially influence biologic properties of AML cells, they are the most important prognostic factors for AML and utilized to classify AML in the WHO classification. Furthermore, recent advances in the understanding of the genetic basis have enabled us to construct novel therapeutic approaches, and some of which are already in clinical trials or applied to daily clinical practice.
論文 | ランダム
- 長崎自動車道と低土かぶりで交差する含水未固結地山におけるNATMの施工--九州新幹線筑紫トンネル(山浦工区)
- 神奈川県 外部評価の有効活用めざし「とにかくやってみよう!」 (特集 普及活動への外部評価システム導入のこころみ(下)) -- (普及活動外部評価の試行取り組みレポート)
- 電気事業 (〔日本自動制御協会〕創立20周年記念特集号) -- (工学システムにおける計測・制御技術の動向)
- 第17回岐阜大学臨床セミナー 教育講演 犬と猫の口腔内腫瘍
- 31G2 高分子電解貭溶液に及ぼす放射線の影響 II