Growth ability in various macaque cell lines of HIV-1 with simian cell-tropism
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概要
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We have recently constructed a series of novel human immunodeficiency viruses(HIV-1s) that are tropic for a macaque cell line (mt ; macaque cell-tropic) to generate andestablish a primate experimental system for HIV-1/AIDS study. In order to determine biologicalproperties of these viruses effectively, several other macaque cell lines with distinctcharacteristics that can be routinely and easily used, instead of primary cells, forinfection experiments are required. In this study, we have examined four macaque celllines for their surface expression of virus receptor molecules and for their genotype of amajor anti-viral capsid gene. Furthermore, we monitored the susceptibility of the celllines to a standard simian immunodeficiency virus (SIV) clone and three representativebasic mt HIV-1 clones. Results obtained here have clearly indicated that these cell linesare exquisitely useful to characterize various SIVs and more importantly, mt HIV-1s.
論文 | ランダム
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