Amphotericin Bの大量経口投与と吸入による深部真菌症の予防の試み：造血器悪性腫瘍患者の剖検例5例での検討

概要

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Autopsy examinations were conducted in five patients with hematological malignancies, especially in search of fungal infections. All of them had several risk factors includind prolonged granulocytopenia, treatment with broad-spectrum antibiotics, anticancer therapy, insertion of central venous catheters and so on. They all receivedprophylactically large doses of oral amphotericin B suspension (2.4 g/d) as well as inhalation of aerosolized amphotericin B, except for one patient who received only oral therapy, but none of them received intravenous administration. Results of postmortem examinations were : 1) immediate causes of death, without exception, were nonmycotic infections, 2) None of the five patients had signs of fungal colonization throughout the digestive tract or in deep organs.
奈良医学会の論文
1989-02-28