Effects of Cations on the Outer Membrane Permeability of Escherichia coli(MEMBRANE PROTEINS AND TRANSPORT-II)

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概要

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• The outer membrane permeability to β-lactam antibiotics was determined with intact Escherichia coli cells treated with various concentrations of NaCl. It was found that the treatment of cells with moderate concentrations of NaCl caused dramatic increase in the diffusion rate of β-lactam across the outer membrane. This increased rate of β-lactam diffusion was not due to the high osmolarity exerted by NaCl, since the elevated osmolarity of the assay medium by sucrose had no significant effect. This increased rate of β-lactam diffusion was restored by addition of a low concentration of MgSO_4 or CaCl_2 into the assay medium. These results were interpreted as that the treatment of intact E. coli cells with moderate concentration of monovalent cations squeezed out divalent cations, which presumably destabilizd the outer membranes, causing electrostatic repulsion of negatively charged lipopolysaccharide molecules in site.

• 東海大学の論文
• 1982-06-14

著者

• Nakae Taiji

  Institute Of Medical Science Tokai University

• HOMMA Toshihiko

  Institute of Medical Sciences and School of Medicine, Tokai University

• Homma Toshihiko

  Institute Of Medical Sciences And School Of Medicine Tokai University

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• The Use of the Laser Light Scattering for the Molecular Weight Determination of Membrane Proteins in Surfactants(MEMBRANE PROTEINS AND TRANSPORT-II)
• The Solute Selectivity of Porin Pores of Escherichia coli and Salmonella typhimurium(MEMBRANE PROTEINS AND TRANSPORT-II)
• Liposome Mediated Dissipation of Valinomycin-Imposed Potassium Potential Across Erythrocytes Membrane
• Effects of Cations on the Outer Membrane Permeability of Escherichia coli(MEMBRANE PROTEINS AND TRANSPORT-II)

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