ビタミンA欠乏ラットにおけるアディポサイトカインの変動とインスリン抵抗性
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In the previous study, a tendency of the glucose intolerance in the vitamin A-deficient rats was observed. In generally, retinol-binding protein (RBP) is known as an insulin resistance factor, and its serum concentration is hard to be affected by the nourishment status of the vitamin A. Therefore we investigated a change of RBP and other adipocytokine to clarify a cause of the glucose intolerance in the vitamin A-deficient rats.Male Wistar-strain rats (N=13) and male type 2 diabetes model (GK) rats (N=12) were purchased from Clea Japan Inc. Each strain rats were divided into the normal-diet group or the vitamin A-deficient diet group. Every rat was trained to daily meal feeding (9:00-18:00) to measure serum glucose. After 6 weeks of these dietary regiments, serum glucose was higher in the GK rats than the Wistar rats. Serum insulin was significantly increased in the GK rats, as compare as the Wistar rats. In the GK rats, a tendency to high insulin concentration was shown in vitamin A deficiency. Serum RBP4 was significantly decreased against the increase of resistin and TNF-α in the vitamin A-deficient rats. Serum adiponectin was not changed in each group. Leptin and visfatin showed tendency or significant decrease in vitamin A-deficient rats.These results suggested that insulin resistance was induced by some adipo-cytokines in vitamin A-deficient rats, but RBP4 was decreased in high insulin group. Therefore, it is thought that the influence of RBP4 on insulin resistance is secondary in vitamin A deficiency.
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