Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress
スポンサーリンク
概要
- 論文の詳細を見る
The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4′,5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FST), in ovariectomized rats. Daily administration of genistein to ovariectomized rats at a dosage of 10 mg/kg of body weight/d for 14 d significantly reduced the immobility time during the FST without changing motor dysfunction. On the other hand, a higher dosage, 100 mg/kg/d, did not have any effects on the immobility time compared with the vehicle control. Repeated administration of genistein at 10 mg/kg of body weight did not affect serotonergic activities in the hippocampus compared to the vehicle control in ovariectomized rats. A 5-min FST trial stimulated these activities. On the other hand, repeated pretreatment with genistein protected against changes in activity during the FST trial. These results suggest that daily consumption of genistein 10 mg/kg/d might have antidepressant-like effect on ovariectomized rats by regulating changes in serotonergic metabolism in the hippocampus under stressful conditions.
論文 | ランダム
- 団塊学園--ホームルームだョ! 全員集合 (永久保存版 「団塊の達人」養成講座--賢く豊かに生きるための知恵と知識 総力特集130ページ!)
- 高品質TEM試料作製トリプルビーム装置「SMI 3000TBシリーズ」 (特集 ナノテク製造・評価装置の最新成果)
- 理系研究者からのコメント (特集 アジアと日本の法) -- (知的財産シンポジウム 文と理,対峙から協働へ--文理融合型知的財産の活用方法を探る)
- 基調講演 日米で発明者・研究者として活動して (特集 アジアと日本の法) -- (知的財産シンポジウム 文と理,対峙から協働へ--文理融合型知的財産の活用方法を探る)
- 特別インタビュー ここが「素晴らしい」日本のマテリアル開発,ここが「おかしい」日本のマテリアル開発 (「MATERIAL STAGE」100号記念に寄せて)