ペプチドを用いた細胞内デリバリー

概要

論文の詳細を見る
Intracellular delivery using membrane-permeable peptide vectors is a recently developed methodology that has been employed to transport various bioactive molecules into cells. The efficient delivery of proteins, drugs, and nano-particles including liposomes has been accomplished using this methodology by conjugation of a peptide vector with the cargo molecules. Arginine-rich peptides, including a basic peptide segment derived from the human immunodeficiency virus type 1 (HIV-1) Tat protein, are categorized into one of the most frequently used peptide vectors, and the significant involvement of endocytosis in the cellular uptake of these peptides has been demonstrated. The structural features of these peptide vectors and the current understandings of their internalization mechanisms are summarized
京都大学低温物質科学研究センターの論文