Dimethylhydrazine (DMH) 誘発ラット大腸aberrant crypt foci (ACF) のdocosahexaenoic acid (DHA) による抑制 (Round Table Discussion I. 消化器癌の発癌抑制効果, 抗プロモーション作用)
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The effect of intragastric gavage administration of docosahexaenoic acid (DHA) on 1, 2-dimethylhydrazine (DMH) -induced aberrant crypt foci formation in the rat colon was investigated. Male F344 rats were treated three times s. c. with 20 mg/kg of DMH and were given intragastrically either 0.7 ml of DHA or water 5 times a week for 4 weeks from the day before the first carcinogen treatment. The total number of DMH-induced aberrant crypt foci per colon was significantly less in the group given DHA than in the control group (42.4±18.7 vs. 122.1±35.3 ; p<0.001). The mean size of aberrant crypt foci, measured as the number of crypts per focus, was significantly smaller in the group given DHA than that in the control group (1.60±0.20 vs. 1.88±0.22 ; p<0.01). The results suggest that DHA suppresses the formation and the growth of aberrant crypt foci and may have a preventive effect on colon carcinogenesis.
- 1992-09-03
論文 | ランダム
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