ヒト胃癌, 非癌部胃粘膜およびヌードマウス可移植性ヒト胃癌におけるEGFR (epidermal growth factor receptor) の定量的検索 (Session III. Epidermal growth factor)
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概要
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Epidermal growth factor (EGF) is a small polypeptide that correlates the tumorigenicity of gastric cancer xenografts in nude mice and invasion and metastasis of human gastric cancer. The effect of EGF is mediated through cell surface receptor (EGFR). EGFR assayed by ^<125>I-EGF binding showed positive (over 10 fmol/mg protein) in 50% (25/50) cases of gastric cancer tissues and 24% (12/50) cases of non-cancerous gastric mucosa. Seven gastric cancers showed binding capacity over 100 fmol/mg protein. Gastric cancers are classified into 2 types : intestinal and diffuse. These 2 types of cancer differ not only in its morphology and growth pattern but also the mucosa from which they originated. Intestinal type of gastric cancer may originate from intestinal metaplasia of the stomach. Eighteen of 29 (62.1%) of diffuse type of cancer showed EGFR-positive in contrast to 7 of 21 (33.3%) in intestinal type (p<0.05). Scirrhous stromal reaction and positive lymph node metastasis cases showed high incidence of EGFR-positive. Four of 7 (57.1%) EGFR-positive cases in non-cancerous mucosa showed none or few metaplastic glands and no correlation was found between EGFR-positive and intestinal metaplasia. All of 7 gastric cancer xenografts in nude mice (4 intestinal and 3 diffuse types) showed EGFR-positive activity. There was a negative correlation between tumor doubling time and EGF binding capacity (p<0.01).
- 1990-09-01
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